Lecithin-cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma. LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.
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See also
- Lecithin cholesterol acyltransferase deficiency
- Acyl-CoA:cholesterol acyltransferase (ACAT)
References
Further reading
External links
- Lecithin Cholesterol Acyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
Source of the article : Wikipedia
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